Kye's is easy to find, located in the Water Tower Square Business Park in Jeffersonville, Indiana, just across the river from Louisville, Kentucky.  Whichever direction you're coming from, use the water tower as your landmark.

From the South
(downtown Louisville, using the Second Street Bridge):
If you’re heading north from Louisville on the Second Street Bridge, take a left at the light at the foot of the bridge.  For Kye’s I, turn right and the building will be on your immediate left.  For Kye’s II proceed straight.

From the South (Nashville):
Stay on I-65 North through downtown Louisville and over the Ohio River.  As you cross the bridge into Indiana, you will want to be in the right hand lane.  Take the very first exit (Jeffersonville, Exit 0).  At the light at the bottom of the exit ramp, turn left on Court Avenue and proceed to the next stoplight.  For Kye’s I, turn right and the building will be on your immediate left.  For Kye’s II proceed straight.

From the East (Lexington):
Follow I-64 West into downtown Louisville, where it will merge with I-65 North. Follow directions above. 

From the West (St. Louis):
Follow I-64 East into downtown Louisville, where it will merge with   I-65 North. Follow directions above. 

From the North (Indianapolis):
Follow I-65 South to Exit 1: 31 South / Stansifer Avenue / 10th Street.  Merge into center lane and go through light.  Continue towards 65 / 31 South and exit in the right lane.  (You will see Kye’s I & II ahead on the right.)  At intersection, turn right at the stoplight.  For Kye’s I, take an immediate right and the building will be on your immediate left.  For Kye’s II proceed straight.

From the North (heading toward the Second Street Bridge):

If you’re heading south through Indiana toward the Second Street Bridge, about a half-block before you get to the bridge itself, continue to the stoplight and turn right.  For Kye’s I, take an immediate right and the building will be on your immediate left.  For Kye’s II proceed straight.