Kye's is easy to find, located in the Water Tower Square Business Park in Jeffersonville, Indiana, just across the river from Louisville, Kentucky.  Whichever direction you're coming from, use the water tower as your landmark.

From the South
(downtown Louisville, using the Second Street Bridge):
Take US 31 heading North across the Second Street Bridge.  At the end of the Bridge take a left at the stoplight. From there you can either go straight for Kye’s II or right onto Missouri Avenue for Kye’s I. 

From the South (Nashville):
Stay on I-65 North through downtown Louisville and over the Ohio River. As you cross the bridge into Indiana, you will want to be in the right hand lane. Take the very first exit (Jeffersonville, Exit 0).  At the light at the bottom of the exit ramp, turn left on Court Avenue. Go straight to the stoplight at the foot of the Second Street Bridge.  At the light, go straight for Kye’s II or right onto Missouri Avenue for Kye’s I. 

From the East (Lexington):
Follow I-64 West into downtown Louisville, where it will merge with I-65 North. Follow directions above. 

From the West (St. Louis):
Follow I-64 East into downtown Louisville, where it will merge with   I-65 North. Follow directions above. 

From the North (Indianapolis):
Follow I-65 South to Jeffersonville and take Exit 1 to US 31. Go straight through one stoplight at Stansifer Avenue and follow US 31 signs to Louisville. BEFORE you get on the Second Street Bridge, there will be a stop light. Take a right at that stop light onto Court Avenue. You can then go straight for Kye’s II or take another right onto Missouri Avenue for Kye’s I.